Novel synthesis of piperazine ring

ABSTRACT

A novel process for preparing a compound of the formula I:  
                 
 
     wherein  
     R 1  denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy or arylalkoxy; R 2  denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy, arylalkoxy, tosyl, formyl, acetyl or amine; and R 3  denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy or arylalkoxy is disclosed. These compounds are useful in the synthesis of the antidepressant mirtazapine and other tetracyclic compounds.

RELATED APPLICATION

[0001] This application claims the benefit under 35 U.S.C. § 119(e) of U.S. Provisional application, Ser. No. 60/130,048, filed Apr. 19, 1999.

FIELD OF THE INVENTION

[0002] The present invention relates to methods for the synthesis of piperazine rings, particularly for the preparation of heterocyclic compounds useful as intermediates in the synthesis of piperazinoazepines such as the antidepressant mirtazapine.

BACKGROUND OF THE INVENTION

[0003] Mirtazapine, also known as 1, 2, 3, 4, 10, 14b-hexahydro-2-methylpyrazine [2,1 -a]pyrido[2,3-c] benzazepine, is an antidepressant suitable for oral administration. It has a tetracyclic chemical structure unrelated to other classes of antidepressants such as selective serotonin reuptake inhibitors (SSRIs), tricyclics or monoamine oxidase inhibitors. Mirtazapine belongs to the piperazinoazepine group of compounds, and has the following structural formula.

[0004] Known methods for the preparation of piperazine ring derivatives have low yields (9-30%), expensive reagents, and many reaction steps (Roderick, W. R. et al., J. Med. Chem 9, 1966, 181-185). It is desirable to have methods for preparing piperazine ring derivatives with fewer steps, high yields and inexpensive raw materials.

SUMMARY OF THE INVENTION

[0005] The present invention relates to a novel process for preparing a compound of the formula I:

[0006] wherein

[0007] R¹ denotes substituted or unsubstituted alkyl, aryl, arylalkoxy, tosyl, formyl, benzoyl, acetyl or amine; R² denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy or arylalkoxy; and R³ denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy or arylalkoxy; by reacting a compound of the formula

[0008] wherein R² and R³ are as defined above and R⁴ and R⁵ are independently selected from the group consisting of fluoro, chloro, bromo and iodo,

[0009] with a compound of the formula H₂N—R¹, wherein R¹ is as defined above. Preferably the reaction is performed in the presence of a solvent. Polar aprotic solvents such as, dimethyl formamide, dimethylacetamide and dimethylsulfoxide are preferred.

DETAILED DESCRIPTION OF THE INVENTION

[0010] The present invention provides a new process for preparing piperazine rings suitable for use in the synthesis of the antidepressant mirtazapine and other tetracyclic compounds such as those disclosed in U.S. Pat. No. 4,062,848 to van der Burg, the contents of which are incorporated herein by reference.

[0011] The process of the present invention comprises the steps of reacting a compound of formula II:

[0012] wherein

[0013] R⁴ and R⁵ are independently any of the of radicals selected from the group that consists of fluoro, chloro, bromo and iodo; and R² and R³ are as defined above; with a compound of the formula H₂N—R¹, wherein R¹ is as defined above. Preferably, R¹ denotes aryl, acetyl, fornyl, benzoyl, amine, or tosyl. Most preferably, R¹ is tosyl. In order to remove any doubt, the tosyl radical is defined as the group of formula VI:

[0014] wherein Me represents a methyl group. Preferably R² denotes methyl, R³ denotes phenyl, R⁴ denotes chloro, and R⁵ denotes chloro.

[0015] Preferably, the compounds of formulae I and II are compounds of formulae IV and V accordingly:

[0016] In a preferred embodiment, the present invention relates to a process for preparing a compound of formula XI:

[0017] wherein Ph represents a phenyl group, which comprises reacting a compound of formula XII:

[0018] with a compound of formula XIII:

[0019] Preferably this reaction takes place in the presence of a strong base such as sodium hydroxide (NaOH), sodium hydride (NaH), potassium hydroxide (KOH), potassium hydride (KH), sodium methoxide (NaOMe) and sodium amide (NaNH₂). Sodium hydroxide and sodium hydride are preferred.

[0020] Preferred solvents for the above reaction are any one or more of the solvents selected from the group that consisting of dimethyl formamide (DMF), dimethyl acetamide (DMAC), dimethyl sulfoxide (DMSO), xylene, benzene, ethylbenzene, acetonitrile, toluene and ethers with high boiling points such as ethyleneglycol dimethyl ether, diethyleneglycol dimethyl ether, and propyleneglycol dimethyl ether.

[0021] The compound of formula XI may be further hydrolized to give the compound of formula XIV:

[0022] The compound of formula XIV is known as 4-methyl-2-phenylpiperazine. Compounds of formula XI may be hydrolyzed by reacting a compound of the formula XI with acid to give compounds of the formula XIV. Preferred acids for the reaction are strong acids such as sulfuric acid (H₂SO₄), hydrochloric acid (HCl), phosphoric acid (H₃PO₄) and p-toluene sulfonic acid. A more preferred acid is sulfuric acid with a concentration of about 98%. Preferably the reaction is carried out in aqueous solution.

[0023] The compound of formula XIV may be used in the preparation of the mirtazapine (1, 2, 3, 4, 10, 14b-hexahydro-2-methyl-pyrazino[2,1-a]pyrido[2,3-c][2] benzazepine), as shown in Schemes 1 and 2 below.

[0024] As shown in Scheme 1, the compound 3-cyano-2-(4-methyl-2-phenyl-1-piperazynyl) pyridine may be prepared starting from 2-chloro-3-cyano-pyridine and 4-methyl-2-phenyl-piperazine.

[0025] Starting from 3-cyano-2-(4-methyl-2-phenyl-1-piperazynyl)pyridine, mirtazapine can be prepared by two routes, which are fuirther presented in Scheme 2:

[0026] In accordance with the present invention, mirtazapine produced by the process of the present invention may be prepared as pharmaceutical compositions that are particularly useful for the treatment of depression. Such compositions comprise mirtazapine with pharmaceutically acceptable carriers and/or excipients known to one of skill in the art.

EXAMPLES

[0027] The following examples are given for the purpose of illustrating the present invention and shall not be construed as being limitations on the scope or spirit of the invention.

Example 1

[0028]

[0029] A suspension of sodium hydride (60%, 1.1 g) in DMF (20 mL) was prepared. p-Toluenesulfonamide (2.2 g) was dissolved in DMF (10 mL) and added continuously to the sodium hydride suspension. After mixing at room temperature the suspension was heated to 60-70° C.

[0030] After that, the solution of beta-chloro-N-methyl-N-chloroethyl phenylethylamine (3 g) in DMF (10 mL) was added dropwise and mixed overnight. The reaction mixture was poured into a mixture of water (21 g) and ice (40 g).

[0031] After 4 hours the precipitate was filtered, washed with water (2×30 mL) and dried in an oven to give 3.3 g of the product.

Example 2 Preparation of 4-methyl-2-phenyl piperazine

[0032]

[0033] Tosyl piperazine (1.2 g) was dissolved in water (1 g) and H₂SO₄ (98%, 3 mL) while heating to 110° C. After 20 minutes at 110-120° C. the reaction mixture was poured into water (10 mL) and ice (20 g).

[0034] The solution was alkalized to pH 13 with NaOH (47%) and the product was extracted into ether. After phase separation the organic phase was evaporated to dryness to give the 4-methyl-2-phenyl piperazine in 75% yield.

[0035] Although certain presently preferred embodiments of the invention have been described herein, it will be apparent to those skilled in the art to which the invention pertains that variations and modifications of the described embodiment may be made without departing from the spirit and scope of the invention. Accordingly, it is intended that the invention be limited only to the extent required by the appended claims and the applicable rules of law. 

We claim:
 1. A method for preparing a compound of the formula

wherein R¹ denotes substituted or unsubstituted alkyl, aryl, arylalkoxy, tosyl, benzoyl, formyl, acetyl or amine; R² denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy or arylalkoxy; and R³ denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy or arylalkoxy, comprising the step of reacting a compound of the formula

wherein R² and R³ are as defined above and R⁴ and R⁵ are independently selected from the group consisting of fluoro, chloro, bromo and iodo, with a compound of the formula H₂N—R¹, wherein R¹ is as defined above.
 2. The method of claim 1, wherein R¹ is selected from the group consisting of aryl, acetyl, formyl, benzoyl, amine and tosyl.
 3. The method of claim 2, wherein R¹ is tosyl.
 4. The method of claim 1, wherein R² is methyl.
 5. The method of claim 1, wherein R³ is phenyl.
 6. The method of claim 1, wherein R⁴ is chloro.
 7. The method of claim 1, wherein R⁵ is chloro.
 8. The method of claim 1, wherein the reaction is performed in a solvent selected from the group consisting of DMF, DMAC, ethers, ethyleneglycol dimethyl ether, diethyleneglycol dimethyl ether, propyleneglycol dimethyl ether, DMSO, xylene, benzene, ethylbenzene, acetonitrile and toluene.
 9. The method of claim 8, wherein said solvent is DMF.
 10. The method of claim 1, further comprising the step of adding a strong base.
 11. The method of claim 10, wherein said strong base is selected from the group consisting of sodium hydroxide, sodium hydride, potassium hydroxide, potassium hydride, sodium methoxide and sodium amide.
 12. The method of claim 11, wherein the base is sodium hydroxide.
 13. The method of claim 11, wherein the base is sodium hydride.
 14. The method of claim 1, further comprising the step of removing R¹ by hydrolysis.
 15. The method of claim 14, wherein R¹ is removed by hydrolysis using a strong acid.
 16. The method of claim 15, wherein the acid is selected from the group consisting of sulfuric acid, hydrochloric acid, phosphoric acid and p-toluene sulfonic acid.
 17. The method of claim 16, wherein the acid is sulfuric acid.
 18. The method of claim 17 wherein the sulfuric acid has a concentration of about 98%.
 19. A method for preparing a compound of the formula:

wherein R¹ denotes substituted or unsubstituted alkyl, aryl, arylalkoxy, tosyl, formyl, benzoyl, acetyl or amine; R² denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy or arylalkoxy; and R³ denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy or arylalkoxy, comprising the step of reacting a compound of the formula

wherein R² and R³ are as defined above and R⁴ and R⁵ are independently selected from the group consisting of fluoro, chloro, bromo and iodo, with a compound of the formula H₂N—R¹, wherein R¹ is as defined above.
 20. The method of claim 19, wherein R¹ is selected from the group consisting of aryl, acetyl, formyl, benzoyl, amine and tosyl.
 21. The method of claim 20, wherein R¹ is tosyl.
 22. The method of claim 19, wherein R² is methyl.
 23. The method of claim 19, wherein R³ is phenyl.
 24. The method of claim 19, wherein R⁴ is chloro.
 25. The method of claim 19, wherein R⁵ is chloro.
 26. The method of claim 19, wherein the reaction is performed in a solvent selected from the group consisting of DMF, DMAC, ethers, ethyleneglycol dimethyl ether, diethyleneglycol dimethyl ether, propyleneglycol dimethyl ether, DMSO, xylene, benzene, ethylbenzene, acetonitrile and toluene.
 27. The method of claim 26, wherein said solvent is DMF.
 28. The method of claim 19, further comprising the step of adding a strong base.
 29. The method of claim 28, wherein the base is selected from the group consisting of sodium hydroxide, sodium hydride, potassium hydroxide, potassium hydride, sodium methoxide and sodium amide.
 30. The method of claim 29 wherein the base is sodium hydride.
 31. The method of claim 29, wherein the strong base is sodium hydroxide.
 32. The method of claim 19, further comprising the step of removing R¹ by hydrolysis.
 33. The method of claim 32, wherein R¹ is removed by hydrolysis using a strong acid.
 34. The method of claim 33, wherein the acid is selected from the group consisting of sulfuric acid, hydrochloric acid, phosphoric acid and p-toluene sulfonic acid.
 35. The method of claim 34, wherein the acid is sulfuric acid.
 36. The method of claim 35 wherein the sulfuric acid has a concentration of about 98%.
 37. A method for preparing a compound of the formula:

which comprises the step of reacting a compound having the formula:

with a compound having the formula:


38. The method of claim 37, wherein the reaction is done in a solvent selected from the group consisting of DMF, DMAC, ethers, ethyleneglycol dimethyl ether, diethyleneglycol dimethyl ether, propyleneglycol dimethyl ether, DMSO, xylene, benzene, ethylbenzene, acetonitrile and toluene.
 39. The method of claim 38, wherein said solvent is DMF.
 40. The method of claim 37, further comprising the step of adding a strong base.
 41. The method of claim 40, wherein said strong base is selected from the group consisting of sodium hydroxide, sodium hydride, potassium hydroxide, potassium hydride, sodium methoxide and sodium amide.
 42. The method of claim 41, wherein the base is sodium hydroxide.
 43. The method of claim 41, wherein the strong base in sodium hydroxide.
 44. The method of claim 37, further comprising the step of removing the tosyl group by hydrolysis.
 45. The method of claim 44, wherein the tosyl group is removed by hydrolysis using a strong acid.
 46. The method of claim 45, wherein the acid is selected from the group consisting of sulfuric acid, hydrochloric acid, phosphoric acid and p-toluene sulfonic acid.
 47. The method of claim 46, wherein the acid is sulfiric acid.
 48. The method of claim 47 wherein the sulfuric acid has a concentration of about 98%.
 49. A compound of the formula:

wherein R¹ denotes substituted or unsubstituted alkyl, aryl, arylalkoxy, tosyl, formyl, benzoyl, acetyl or amine; R² denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy or arylalkoxy; and R³ denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy or arylalkox.
 50. A compound of the formula: 